Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose response is carefully titrated. The tablets are marketed with a score providing an option to split. The tablets were analyzed using novel analytical tool such as near infrared chemical imaging to visualize the distribution of levothyroxine. Assay was not significantly different for whole versus split tablets irrespective of method of splitting hand or splitter, and splitting also had no measurable impact on the stability. Chemical imaging data revealed that the distribution of levothyroxine was heterogeneous and was dependent on type of binder and the process used in the manufacture of tablets. Splitting such tablets could prove detrimental if sub- or super-potency becomes an issue. It also allows the practitioner to administer lower dose to better titrate the dose and facilitate administration of large tablets to patients that may find difficulty swallowing as the whole tablets, e.

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Below, we briefly describe these conditions. These hormones are very important because they affect your metabolism. Synthroid is approved for use in people with thyrotropin-dependent well-differentiated thyroid cancer. When given as part of thyroid cancer treatment, Synthroid is used along with radioactive iodine treatment and surgery. Synthroid contains the active drug levothyroxine. Synthroid is approved for use in people of all ages who have reduced thyroid function. This includes infants, children, adolescents, and adults. Synthroid can cause mild or serious side effects. Even small changes in your Synthroid dose may cause large changes in your hormone levels, which may cause side effects. In some cases, your doctor may need to adjust your dosage of the drug.

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Adverse reactions associated with SYNTHROID therapy are primarily those of hyperthyroidism due to therapeutic overdosage: arrhythmias, myocardial infarction, dyspnea, muscle spasm, headache, nervousness, irritability, insomnia, tremors, muscle weakness, increased appetite, weight loss, diarrhea, heat intolerance, menstrual irregularities, and skin rash. SYNTHROID is indicated as a replacement therapy in primary thyroidal, secondary pituitary, and tertiary hypothalamic congenital or acquired hypothyroidism. Administer SYNTHROID to infants and children who cannot swallow intact tablets by crushing the tablet, suspending the freshly crushed tablet in a small amount 5 to 10 mL or 1 to 2 teaspoons of water and immediately administering the suspension by spoon or dropper. The dose of SYNTHROID for hypothyroidism or pituitary TSH suppression depends on a variety of factors including: the patient's age, body weight, cardiovascular status, concomitant medical conditions including pregnancy, concomitant medications, co-administered food and the specific nature of the condition being treated. There are risks to the mother and fetus associated with untreated hypothyroidism in pregnancy.

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The drug comes as a tablet that you swallow. The active ingredient in Synthroid is levothyroxine. An active ingredient is what makes a drug work. This article describes the dosages of Synthroid, as well as its strengths and how to take it. The tablets come in different colors depending on which strength they are. Note: Synthroid comes in micrograms rather than milligrams mg.

Because of increased prevalence of cardiovascular disease among the elderly, initiate therapy at less than full replacement dose; atrial arrhythmias can occur in elderly patients; atrial fibrillation is the most common of arrhythmias observed with levothyroxine overtreatment in the elderly. Thyroid hormones, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction; larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Proper dose titration and careful monitoring is critical to prevent persistence of hypothyroidism or development of hyperthyroidism. Over-treatment with levothyroxine may cause increase synthroid .112 mg heart rate, cardiac wall thickness, and cardiac contractility; may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients; monitor patients receiving concomitant levothyroxine and sympathomimetic agents for signs and symptoms of coronary insufficiency; initiate lower dose in elderly, those with angina pectoris, cardiovascular disease, or in those with severe hypothyroidism. Over- or under-treatment with levothyroxine may have negative effects on growth and development, cardiovascular function, bone metabolism, reproductive function, cognitive function, emotional state, gastrointestinal function, and on glucose and lipid metabolism; titrate dose carefully and monitor response to titration to avoid these effects.

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It is not intended, nor should it be interpreted, as medical advice or directions of any kind. Although all these medications are synthetic levothyroxine, they are not identical. The manufacturing processes differ, as do the fillers and dyes. These differences may affect the absorption of the drug. The absorption affects how much of the drug your body actually receives.

Even though Synthroid and Levothyroxine contain the same active ingredient, they may not be tolerated equally among all patients. Learn how to identify if you are taking the right type of medication and when to consider switching in this post The answer is yes, there may actually be a difference despite these medications being almost exactly the same. And even though the difference is not big, it may actually matter to certain people especially those who are sensitive. The active thyroid hormone and the active ingredient in both medications is the thyroid hormone Thyroxine. So we know that the difference between these medications probably has little to do with the active ingredient synthroid .112 mg more to do with the inactive ingredients.

Recent shortages and synthroid .112 mg of certain desiccated thyroid medications have put patients in the position of quickly finding alternative medications. Some patients, who may have taken the same thyroid medication for years, suddenly found themselves needing to find a new brand. A compounding pharmacy can be helpful for bridging any gaps in availability due to manufacturer shortages. All desiccated thyroid brands that are commercially available use porcine thyroid as their active ingredient. In all brand name desiccated thyroid extract medications, the active ingredient is Thyroid USP which means it must meet the same standard.

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