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Etoricoxib belongs to the selective COX-2 inhibitor class of drugs and may be associated with an increased risk of coronary and cerebrovascular thrombotic events, heart failure, hypertension, and oedema compared with placebo and some non-steroidal anti-inflammatory arcoxia purchases. Other important risks to consider with etoricoxib are effects on the gastrointestinal system, particularly those of perforation, ulceration, or bleeding. From these trials, there is evidence that the mg dose is effective in rheumatoid arthritis and ankylosing spondylitis. However, for some patients, the mg dose will be more efficacious, although prediction of which patients might benefit from the higher dose is not possible. Therefore, the recommended starting dose for treatment of rheumatoid arthritis or ankylosing spondylitis has been reduced to 60 mg once daily, with the option to increase to a maximum of 90 mg once daily if necessary.

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Etoricoxib is a selective inhibitor of COX-2 cyclooxygenase 2 indicated in the symptomatic relief of osteoarthritis OA, mg once daily od, rheumatoid arthritis RA, 90mg od and the pain and signs of inflammation associated with acute gouty arthritis mg od. This referral procedure relates to a request for arbitration concerning a type II variation for a new indication to include treatment of ankylosing spondylitis AS, at a recommended daily dose of 90mg. At the end of the mutual recognition procedure, there was a discrepancy between different European Union EU Member States regarding the safety of etoricoxib at the 90mg dose in the new proposed indication. Karl Broich and Co-Rapporteur Dr. Matthew Thatcher were appointed.

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