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Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local and systemic actions. The environment in the rectum is considered relatively constant and stable and has low enzymatic activity in comparison to other sections of the gastrointestinal tract. Therefore, rectal drug delivery can provide significant local and systemic levels for various drugs, despite the relatively small surface area of the rectal mucosa. However, despite the pharmaceutical advances in rectal drug delivery, very few of them have translated to the clinical phase. The oral route is the most convenient route for drug administration. However, there are circumstances where this is not possible from either a clinical or pharmaceutical perspective de Boer et al.

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