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Lotrel amlodipine besylate and benazepril hydrochloride is a combination of an angiotensin -converting enzyme ACE inhibitor and a calcium channel blocker used for treatment of high blood pressure hypertension that is resistant to treatment by either amilodipine or benzapril alone.
Common side effects include swelling, feeling tired, abdominal pain, and nausea. Amlodipine was patented in, and approved for medical use in Amlodipine is used in the management of hypertension and coronary artery disease in people with either stable angina where chest pain occurs mostly after physical or emotional stress or vasospastic angina where it occurs in cycles and without heart failure. It lotensin norvasc 5mg be used as either monotherapy or combination therapy for the management of hypertension or coronary artery disease.
General-Not recommended as first line therapy in the elderly. Peripheral edema may be common. Lower drug clearance may result in increased sensitivity to blood pressure lowering effects. Gastrointestinal-May cause or worsen pre-existing constipation. Renal-Monitor for increased serum creatinine or hyperkalemia.
WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Common adverse reactions include cough and edema.
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Before the patients were admitted to the trial, at the end of the placebo run-in and the benazepril run-in period and at the end of weeks 4 and lotensin norvasc 5mg of the treatment period, sitting and standing blood pressure BP, heart rate HR, and body weight were measured h after the intake of the trial medication. The tolerability was good in the three treatment groups. No significant abnormal laboratory data were detected.
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Stop using this medication and tell your doctor right away if you become pregnant. Amlodipine and benazepril may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. You should not use this medication if: you are allergic to amlodipine Norvasc or benazepril Lotensin ; you have ever had angioedema hives or severe swelling of deep skin tissues sometimes caused by allergic reaction ; or you are allergic to any other ACE inhibitor, such as captopril Capoten, fosinopril Monopril, enalapril Vasotec, lisinopril Prinivil, Zestril, moexipril Univasc, perindopril Aceon, quinapril Accupril, ramipril Altace, or trandolapril Mavik.
To make sure you can safely take amlodipine and benazepril, tell your doctor if you have any of these other conditions: kidney disease or if you are on dialysis ; liver disease; heart disease or congestive heart failure; diabetes; or if you are on a low-salt diet. Do not use amlodipine and benazepril if you are pregnant. Use effective birth control while taking amlodipine and benazepril. Do not use this medication without telling your doctor if you are breast-feeding a baby. Your doctor may occasionally change your dose to make sure you get the best results.
Individuals with bilateral renal artery stenosis narrowing of the arteries that supply the kidneys may experience worsening of kidney function, and people who have had a severe reaction to ACE inhibitors probably should avoid them. It may take up to a month for coughing to subside, and if one ACE inhibitor causes cough it is likely that the others will too. The most serious, but rare, side effects of ACE inhibitors are What is the dosage for calcium channel blockers vs.
For example, the recommended starting dose of amlodipine, a common CCB, for children and adults is 2. The maximum dose for adults is 10 mg once daily and the maximum dose for children is 5 mg once daily. Amlodipine can be taken with or without food. Amlodipine is inactivated mainly by the liver, and dosages may need to be lowered in patients with liver dysfunction.
ACE inhibitors are often supplied as oral tablet. For example, the usual starting dose of benazepril, a common ACE inhibitor, is 10 mg daily. If patients are taking a diuretic water pill the starting dose is 5 mg daily. Doses may be increased to mg once daily or divided and administered twice daily. What drugs interact with calcium channel blockers and ACE inhibitors? The interactions of calcium channel blockers occur with verapamil Calan, Isoptin or diltiazem Cardizem. The interaction occurs because verapamil and diltiazem decrease the elimination of a number of drugs by the liver.
Through this mechanism, verapamil and diltiazem may reduce the elimination and increase the blood levels of carbamazepine Tegretol, simvastatin Zocor, atorvastatin Lipitor, and lovastatin Mevacor. This can lead to toxicity from these drugs. Grapefruit juice approximately ml may elevate blood concentrations of felodipine Plendil, verapamil Calan, Isoptin, nisoldipine Sular, nifedipine Adalat, Procardia, nicardipine Cardene, and possibly amlodipine Norvasc.
Do not take amlodipine and benazepril if you are pregnant. Amlodipine and benazepril may harm the fetus. The combination of amlodipine and benazepril is used to treat high blood pressure.
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The combination of amlodipine and benazepril is used cheap crestor 5mg treat high blood pressure hypertension in people who have failed to achieve the desired antihypertensive effect on one of these medications alone or who developed edema swelling when taking amlodipine alone. Amlodipine is a calcium channel blocker and it widens blood vessels. Benazepril is an ACE inhibitor that blocks a chemical that tightens blood vessels. Together, the combination of amlodipine and benazepril improves blood flow and reduces the workload of the heart. The usual starting dose is amlodipine 2.
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Sorry, something went wrong and the translator is not available. Sorry, something went wrong with the translation request. Never administer any drug without your veterinarian's input. Serious side effects or death can occur if you use drugs on your pet without your veterinarian's advice.
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They point out that while U. Benazepril was increased to 40 mg at one month, and after two months investigators titrated doses to achieve target blood pressures.
- The aim of this study was to evaluate the effect of benazepril addition to amlodipine antihypertensive treatment on ankle—foot volume AFV and pretibial subcutaneous tissue pressure PSTP, two objective measures of ankle oedema.
- Drugs that act directly on the renin-angiotensin system RAS can cause injury and death to the developing fetus.
- Amlodipine and benazepril is a combination of medicines that are used to treat high blood pressure hypertension.
- Generic drugs usually cost less than brand-name drugs.
- Angiotensin converting enzyme ACE inhibitor therapy provides improvement in cardiovascular structure beyond its effect on blood pressure BP, though intensive BP reduction is well-known to positively alter the course of cardiovascular disease.
- If you take other medicines that lower blood pressure, such as ramipril or lisinopril, at the same time as amlodipine, the combination can sometimes lower your blood pressure too much.
This medicine contains an ACE inhibitor and a calcium channel blocker. Brand Name s: Lotrel There may be other brand names for this medicine.
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The optimal combination drug therapy for hypertension is not established, although current U. We hypothesized that treatment with the combination of an angiotensin-converting—enzyme ACE inhibitor and a dihydropyridine calcium-channel blocker would be more effective in reducing the rate of cardiovascular events than treatment with an ACE inhibitor plus a thiazide diuretic.
Authored by Dr. Aviva Lubin, MD
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