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Due to a reduction in vasoconstriction, this leads to a decrease in peripheral vascular resistance and blood pressure falls. Adverse effects, dry mouth, sedation and drowsiness, can be severe, limiting the usefulness of these two drugs.
- Chronic bronchitis is characterized by hypertrophy of the glands of the airway and excessive production of mucus.
- They should be used with caution in older people (because of the risk of serious gastrointestinal side effects and drug-induced hepatitis), in allergic disorders including asthma, during pregnancy and in coagulation disorders.
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- Consequently, good practice that is regarded as quite basic to other health professions has been overlooked and not implemented.
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Although generally not as important as renal excretion, other routes of excretion account for elimination of some drugs. It is possible for drugs to move back across the intestinal wall by diffusion or active transport and be lost in faeces.
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