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It is also used to treat allergy symptoms such as rash, itching, and runny nose.

When deciding whether to use promethazine during pregnancy it is important to weigh up the potential benefits to your health and wellbeing against any possible risks to you or your baby, some of which may depend on how many weeks pregnant you are. Your doctor or specialist will be able to help you make decisions about your treatment. If you are taking any medicines while pregnant you can discuss this with your doctor. You can then decide together whether ongoing treatment is appropriate, and, if so, your doctor will ensure that you are taking the most effective dose. It is mainly during this time that some medicines are known to cause birth defects. Over 5, women taking promethazine in early pregnancy have been studied as it is used quite commonly to treat pregnancy sickness.

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However, despite its familiarity, its use is not without risks. Promethazine is a phenothiazine derivative that possesses histamine H1-blocking, anti-muscarinic, sedative, antimotion sickness, anti-emetic and anti-cholinergic effects. Indications for promethazine include the amelioration of allergic reactions to blood or plasma or, after acute symptoms have been controlled, as an adjunct to epinephrine and other standard measures in anaphylaxis. Other uses include sedation, relief of apprehension, active treatment of motion sickness, and prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. It is also used in surgical situations e. Its clinical effects are apparent within five minutes of an intravenous IV injection. Because of its longstanding use, clinicians have grown comfortable with promethazine despite its serious risks. A postoperative patient returned to the inpatient unit with left-hand discoloration and complaints of tingling in her arm; her fingers and palm became purple and cool to touch, shortly after receiving Phenergan IV in the recovery room. Several days later, the hand swelling subsided; the hand was less tender, without tingling, and the patient improved.

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Common side effects include confusion and sleepiness. Another notable use of promethazine is as a local anesthetic, by blockade of phenergan gel 25 mg channels. In, the US Supreme Court ruled on a product liability case involving promethazine. On September 9, the FDA required a boxed warning be put on promethazine for injection, stating the contraindication for subcutaneous administration. From Wikipedia, the free encyclopedia. Clinical Pharmacokinetics.

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Each rectal suppository contains It is soluble in water and freely soluble in alcohol. Perennial and seasonal allergic rhinitis. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Preoperative, postoperative, or obstetric sedation.

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Common side effects of promethazine include confusion and sleepiness; 4 consumption of alcohol or other sedatives can phenergan gel 25 mg these symptoms worse. This also means high doses act as a deliriant. Some documented side effects include Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. Promethazine is listed as one of the drugs of highest anticholinergic activity in a study of anticholinergenic burden, including long-term cognitive impairment. Promethazine in overdose can produce signs and symptoms including CNS depression, hypotension, respiratory depression, unconsciousness, and sudden death.

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It may also be used to treat allergic conditions such as rash, itching, and runny nose. Phenergan Syrup should be taken with or without food, but take it at the same time every day to get the phenergan gel 25 mg benefit. The dose and how often you take it depend on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

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Promethazine transdermal gel aka Phenergan Gel is used to treat nausea and vomiting. Since oral tablets or suppositories are not always desirable for treating nausea, a transdermal gel may be custom-made by a compounding pharmacy.

This sheet talks about whether exposure to promethazine may increase the risk for birth defects over that background risk.
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What is promethazine, and how does it work mechanism of action?
Fast acting antihistamine for relief of symptoms of allergies and allergic conditions such as hayfever, eczema, dermatitis and hives, nasal congestion and reactions to insect bites and stings.
Promethazine reduces the permeability of capillaries, swelling of the mucous membranes, itching.
Promethazine is a medicine used to treat nausea and vomiting.
An asthma attack is cheap promethazine canada a goal of type promethazine gel 1 diabetes cell therapy research efforts employ lab-grown islet cells no longer available in this research.

It blocks the effect of histamine, a chemical in the body that causes symptoms of allergic reactions. Promethazine comes as a tablet, oral solution liquid, rectal suppository, and a liquid to be injected into a muscle.

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We are now a c3 non-profit organization, so your donations are tax-deductible. When chemotherapy is given, it can cause histamine to be released.

The elderly represent the fastest growing segment of the population all over the world, and the most common skin complaint in this age group is pruritus, due to a multitude of variables physical and cognitive limitations, multiple comorbid conditions, and polypharmacy. To date, there is no universally accepted therapy. Most patients cannot deal with their pruritus without taking antihistamines AHs daily. Similar to histamine, AHs have organ-specific efficacy and adverse effects. Promethazine affects ligand gated ion channels such as purinergic P2 or cholinergic ACh receptors and voltage dependent ion channels such as sodium, calcium, or potassium buy tolterodine. Since its first introduction in, it has been used for prevention and treatment of nausea and vomiting caused by narcotic therapy, migraine episodes, cancer chemotherapy, and so forth.

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Promethazine may cause breathing to slow or stop, and may cause death in children. Promethazine should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older. Promethazine should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital Luminal, medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis runny nose and watery eyes caused by allergy to pollen, mold or dust, allergic conjunctivitis red, watery eyes caused by allergies, allergic skin reactions, and allergic reactions to blood or plasma products. Promethazine is used with other medications to treat anaphylaxis sudden, severe allergic reactions and the symptoms of the common cold such as sneezing, cough, and runny nose.