Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Zyprexa olanzapine is an atypical antipsychotic medication used in the treatment of bipolar disorder, schizophrenia, and treatment-resistant depression. Before taking Zyprexa, it's helpful to understand how it's used, the potential side effects, and any precautions you should consider. Older adults with dementia should not take Zyprexa due to an increased risk of death. Zyprexa can also interact with other drugs, like diazepam and carbamazepine.

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Common side effects include weight gain, movement disorders, dizziness, feeling tired, constipation, and dry mouth. Olanzapine was patented in and approved for medical use in the United States in The first-line psychiatric treatment for schizophrenia is antipsychotic medication; with olanzapine being one such medication. National Institute for Health and Care Excellence, the British Association for Psychopharmacology, and the World Federation of Societies for Biological Psychiatry suggest that there is little difference in effectiveness between antipsychotics in prevention of relapse, and recommend that the specific choice of antipsychotic be chosen based on a person's preference and the drug's side effect profile. Agency for Healthcare Research and Quality concludes that olanzapine is not different from haloperidol in the treatment of positive symptoms and general psychopathology, or in overall assessment, but that it is superior for the treatment of negative and depressive symptoms. In a comparison of 15 antipsychotic drugs in schizophrenia, olanzapine was ranked third in efficacy. Olanzapine caused less extrapyramidal side effects, less akathisia, but caused significantly more weight gain, serum cholesterol increase, and triglyceride increase than haloperidol. Olanzapine is recommended by the National Institute of Health and Care Excellence as a first line therapy for the treatment of acute mania in bipolar disorder. The Network for Mood and Anxiety Treatments CANMAT recommends olanzapine as a first line maintenance treatment in bipolar disorder and the combination of olanzapine with fluoxetine as second line treatment for bipolar depression.

It is very important that you take the medicine at about the same time every day. It will work best if you do this. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time. Please tell your doctor and pharmacist about all the medicines you take.

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Or in a crisis, text NAMI to All FDA black box warnings are at the end of this fact sheet. Olanzapine may also be helpful when prescribed off-label for prevention of chemotherapy-associated acute and delayed nausea or vomiting, chemotherapy-associated breakthrough nausea or vomiting, delirium, delusional parasitosis, post-traumatic stress disorder, Tourette syndrome, and other mental health conditions. Your mental health provider should justify his or her thinking in recommending and off-label treatment. They should be clear about the limits of the research around that medication and if there are any other options.

Olanzapine is used to treat the zyprexa 7.5 mg tablets of psychotic conditions such as schizophrenia and bipolar disorder manic depression in adults and children who are at least 13 years old. Olanzapine is sometimes used together with other antipsychotic medications or antidepressants. Long-term use of olanzapine can cause a serious movement disorder that may not be reversible. Symptoms include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take olanzapine, the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults.

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These types of medication are seen as a better choice for people with Alzheimer's than other older antipsychotic medications. However, Zyprexa is not approved by the US Food and Drug Administration for the treatment of zyprexa 7.5 mg tablet in older adults with dementia. Antipsychotic medicines are psychotropic medications that treat the symptoms of schizophrenia such as hallucinations, paranoia, and delusions. Atypical antipsychotic medications were first introduced in the s. Atypical antipsychotic medications have a number of distinct differences and have been marketed as drugs that have fewer major neurological side effects such as extrapyramidal symptoms and low rates of tardive dyskinesia.

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Indicated for depressive episodes associated with bipolar I disorder in combination with fluoxetine. Safety of coadministered doses greater than olanzapine 18 mg with fluoxetine 75 mg have not been evaluated. Off-label use for prevention of chemotherapy associated nausea or vomiting in combination with 5-HT3 antagonist and dexamethasone N Engl J Med ; Breakthrough nausea and vomiting: mg PO qDay for 3 days, when not used for acute and delayed emesis prevention. Safety of coadministered doses greater than olanzapine 12 mg with fluoxetine 50 mg have not been in pediatric clinical studies. Tardive dyskinesia may remit, partially or completely, if antipsychotic treatment withdrawn; however, antipsychotic treatment, itself, may suppress or partially suppress signs and symptoms of syndrome and possibly mask underlying process; effect symptomatic suppression has upon long-term course of syndrome unknown.

Author: Eli Lilly Nederland B. It is available as tablets round and white: 2. Zyprexa is used to treat adults with schizophrenia. Schizophrenia is a mental illness that has a number of symptoms, including disorganised thinking and speech, hallucinations hearing or seeing things that are not there, suspiciousness and delusions mistaken beliefs. Zyprexa is also used to zyprexa 7.5 mg tablet moderate to severe manic episodes extremely high mood in adults. It can also be used to prevent the recurrence of these episodes when symptoms come back in adults with bipolar disorder a mental illness with alternating periods of high mood and depression who have responded to an initial course of treatment.

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