Personalized dosing based on patients' cytochrome P genotypes was further associated with fewer and less severe adverse effects among patients with major depressive disorder MDD. There were, though, no differences in depression symptom changes between patients dosed based on their CYP genotypes and those receiving usual care. All participants underwent CYP2D6 and CYP2C19 genotyping using established workflows at the participating institutes to establish whether they had a poor, intermediate, normal, or ultra-rapid metabolizer phenotype. In all, 56 participants were in the PIT arm and 55 in the usual care arm. Patients in the PIT group reached a therapeutic plasma concentration five days faster than the control group, within a mean of The PIT group further experienced fewer and less severe adverse effects.

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