Learn about the medical, dental, pharmacy, behavioral, and voluntary benefits your employer may offer. Do not use if you are pregnant. You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril such as Entresto. If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren a blood pressure medicine.

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Hydrochlorothiazide, Lisinopril dihydrate. ACE inhibitors can cause hyperkalaemia because they inhibit the release of aldosterone. Potassium-sparing diuretics and angiotensin-receptor blockers should be used with caution in patients receiving ACE inhibitors, and serum potassium and renal function should be monitored see section 4. Elevations in serum potassium have been observed in some patients treated with ACE inhibitors, including lisinopril. Patients at risk for the development of hyperkalaemia include those with renal insufficiency, diabetes mellitus, or those using concomitant potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes, or those patients taking other drugs associated with increases in serum potassium e. If concomitant use of the abovementioned agents is deemed appropriate, regular monitoring of serum potassium is recommended see section 4. Some drugs if given concomitantly with ACE inhibitors may increase the risk of angioedema see section 4. Medicines increasing the risk of angioedema. Drugs that may increase the risk of angioedema.

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Lisinopril: The mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension. Hydrochlorothiazide: The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not usually affect normal blood pressure. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity increase in aldosterone secretion, increases in urinary potassium loss and decrease in serum potassium.

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Tell your doctor if you are having or are going to have treatment to lower the effects of an allergy such as insect stings desensitisation treatment. Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Low blood pressure may be aggravated by alcohol, barbiturates or anaesthetics. You may notice dizziness when standing up. Tell your doctor if you are breast-feeding or about to start breast-feeding.

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Each tablet contains lisinopril dihydrate equivalent to 20 mg anhydrous lisinopril and hydrochlorothiazide The usual dosage is one tablet, administered once daily. In general, if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks at this dose level, the dose can be increased to two tablets administered once daily. The recommended dose of lisinopril, when used alone, in mild renal insufficiency, is 5 to 10 mg. If zestoretic 12.5 mg is not possible, treatment should be started with lisinopril alone, in a 5 mg dose. In clinical studies the efficacy and tolerability of lisinopril and hydrochlorothiazide, administered concomitantly, were similar in both elderly and younger hypertensive patients.

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Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure hypertension. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood zestoretic 12.5 mg can reduce the risk of strokes and heart attacks.

Hydrochlorothiazide; lisinopril is classified as FDA pregnancy risk category Zestoretic 12.5 mg. Once pregnancy is detected, every effort should be made to discontinue hydrochlorothiazide; lisinopril therapy. Women of child-bearing age should be made aware of the potential risk and hydrochlorothiazide; lisinopril should only be given after careful counseling and consideration of individual risks and benefits. When used during the second and third trimesters, drugs that affect the renin-angiotensin system e. Other potential neonatal adverse effects include skull hypoplasia, anuria, and hypotension.

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