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UK, remember your settings and improve government services. Etoricoxib belongs to the selective COX-2 inhibitor class of drugs and may be associated with an increased risk of coronary and cerebrovascular thrombotic events, heart failure, hypertension, and oedema compared with placebo and some non-steroidal anti-inflammatory drugs. Other important risks to consider with etoricoxib are effects on the gastrointestinal system, particularly those of perforation, ulceration, or bleeding. From these trials, there is evidence that the mg dose is effective in rheumatoid arthritis and ankylosing spondylitis. However, for some patients, the mg dose will be more efficacious, although prediction of which patients might benefit from the higher dose is not possible. Therefore, the recommended starting dose for treatment of rheumatoid arthritis or ankylosing spondylitis has been reduced to 60 mg once daily, with the option to increase to a maximum of 90 mg once daily if necessary. Letter sent to healthcare professionals in September It will take only 2 minutes to fill in. Etoricoxib Arcoxia: revised dose recommendation for rheumatoid arthritis and ankylosing spondylitis. Therapeutic area: Pain management and palliation, Rheumatology.
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Etoricoxib is a selective inhibitor of COX-2 cyclooxygenase 2 indicated in the symptomatic relief of osteoarthritis OA, mg once daily od, rheumatoid arthritis RA, 90mg od and the pain and signs of inflammation associated with acute gouty arthritis mg od. This referral procedure relates to a request for arbitration concerning a type II variation for a new indication to include treatment of ankylosing spondylitis AS, at a recommended daily dose of 90mg. At the end of the mutual recognition procedure, there was a discrepancy between different European Union EU Member States regarding the safety of etoricoxib at the 90mg dose in the new proposed indication. Karl Broich and Co-Rapporteur Dr. Matthew Thatcher were cheap arcoxia drug. The referral procedure was initiated on 20 September with the adoption of a CHMP list of questions that were to be addressed by the marketing authorisation holders MAHs.
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Allergic disorders; cardiac impairment NSAIDs may impair renal function ; coagulation defects; connective-tissue disorders; dehydration risk of renal impairment ; history of cardiac failure; history of gastro-intestinal disorders; hypertension; left ventricular dysfunction; may mask symptoms of infection; oedema; risk factors for cardiovascular events. Arrhythmias; asthenia; bronchospasm; constipation; diarrhoea; dizziness; fluid retention; gastrointestinal discomfort; gastrointestinal disorders; headache; hypertension; increased risk of infection; influenza like illness; nausea; oedema; oral ulceration; palpitations; skin reactions; vomiting. Alertness decreased; anaemia; angina pectoris; anxiety; appetite abnormal; cerebrovascular insufficiency; chest pain; congestive heart failure; conjunctivitis; cough; depression; drowsiness; dry mouth; dyspnoea; flushing; haemorrhage; buy panadol extra hyperkalaemia; hypersensitivity; insomnia; irritable bowel syndrome; leucopenia; myocardial infarction; pancreatitis; proteinuria; renal failure more common in patients with pre-existing renal impairment ; sensation abnormal; taste altered; thrombocytopenia; tinnitus; vasculitis; vertigo; vision blurred; weight increased. Angioedema; confusion; hepatic disorders; muscle complaints; severe cutaneous adverse reactions SCARs ; shock. Contraindicated in patients with a history of hypersensitivity to aspirin or any other NSAID—which includes those in whom attacks of asthma, angioedema, urticaria or rhinitis have been precipitated by aspirin or any other NSAID. Caution—long-term use of some NSAIDs is associated with reduced female fertility, which is reversible on stopping treatment.
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It was patented in and approved for medical use in Because of these results, some drugs were withdrawn from the market rofecoxib, in September and valdecoxib in April
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Etoricoxib is a cyclo-oxygenase enzyme type 2 COX-2 inhibitor. This means that it blocks the action of COX-2, an enzyme that is cheap arcoxia drug in the inflammation process. As a result, etoricoxib reduces inflammation and pain. Etoricoxib-containing medicines 3 are authorised by regulatory authorities in Member States. The etoricoxib-containing medicine Arcoxia is currently being assessed to determine whether it can also be used to treat ankylosing spondylitis at a dose of 90 mg once a day.

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