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Nove de Julho, Sao Paulo, Brazil. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination xeloda cost canada, but is not yet approved by the UK National Institute for Health and Clinical Excellence NICE in the adjuvant setting. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. The effectiveness of capecitabine in the metastatic setting provided a rationale for its use as adjuvant therapy for colon cancer. A large, randomised phase III study X-ACT was undertaken to compare the efficacy and tolerability of adjuvant oral capecitabine vs bolus i. In addition, an improved safety profile was noted in favour of capecitabine Scheithauer et al, ; Twelves et al, Patients have long expressed a preference for oral fluoropyrimidine therapy instead of i. However, with ever-increasing pressures to control medical costs, the decision of whether or not to use a treatment may not be based on clinical effectiveness alone.

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