Medication non-adherence in patients with schizophrenia continues to be a significant problem and threatens successful treatment outcomes. Medication non-adherence is often associated with negative consequences, including symptom exacerbation, more frequent emergency room visits, re-hospitalizations and relapse. Olanzapine LAI appears to be an effective antipsychotic at dosages of mg every 2 weeks, mg every 2 weeks and mg every 4 weeks in patients with acute schizophrenia, and at mg every 2 weeks, mg every 2 weeks and at mg every 4 weeks for the maintenance treatment of stable patients. Oral supplementation appears not to be needed, particularly not at the onset of treatment with the LAI as is necessary with risperidone LAI. Its efficacy is in general comparable to the efficacy seen with oral olanzapine at a corresponding dose. The side effect profile is also comparable to the side effects observed with oral olanzapine, including lower rates of extrapyramidal symptoms, prolactin elevation and cardiovascular side effects, but significant metabolic effects. The latter include significant weight gain, lipid abnormalities and glucose dysregulation.

When prescribing, dispensing or administering, check that this is the correct preparation—this preparation is used for maintenance treatment and should not be used for the rapid control of an acute episode. An ECG may be required, particularly if physical examination identifies cardiovascular risk factors, personal history of cardiovascular disease, or if the patient is being admitted as an inpatient. See also Prescribing in the elderly. Bone-marrow depression; hypereosinophilic disorders; low leucocyte count; low neutrophil count; myeloproliferative disease; paralytic ileus; when transferring from oral to depot therapy, the dose by mouth should be reduced gradually. Agranulocytosis; confusion; embolism and thrombosis; neuroleptic malignant syndrome discontinue—potentially fatal. Phenothiazines cause less depression of consciousness and respiration than other sedatives.

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Efficacy was established in two clinical trials in patients with schizophrenia: one 8-week trial in adults and one maintenance trial in adults. See Table 1 for dosing recommendations. After each injection, patients must be observed at the healthcare facility by a healthcare professional for at least 3 hours. Analyses of seventeen placebo-controlled trials modal duration of 10 weeks, largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1. Over the course of a typical week controlled trial, the rate of death in drug-treated patients was about 4. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular e. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality.

Olanzapine long-acting injection will be given to you by your clinic doctor or nurse every weeks. There are a number of side-effects which you could experience from the treatment. If you are concerned about any, you should discuss them with your doctor. You will have been prescribed it to maintain symptom control of schizophrenia. Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs, feeling unusually zyprexa 300mg, and becoming withdrawn.

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Antipsychotic drug therapy generally is reserved for patients who have severe symptoms or when associated agitation, combativeness, or violent behavior puts the patient or others in danger. Current evidence indicates that the atypical antipsychotics can provide modest improvement in behavioral manifestations; some evidence suggests that efficacy may be better for psychosis than for other manifestations. Antipsychotic efficacy appears to be similar among available agents and therefore the choice of agent should be based on adverse effect profile and other patient considerations; to minimize adverse effects, the lowest possible effective dose should be used. Otsuka America Pharmaceutical, Inc. Janssen Pharmaceuticals, Inc. Target Generic Agent Name s.

You must be monitored by a health care professional for at least 3 hours after each dose is given. It is important that you keep taking each dose of this medicine on time even if you are feeling well. Please tell your doctor and pharmacist about all the medicines you take. Also tell them about any vitamins, herbal medicines, or anything else you take for your health. Talk to your doctor before taking other medicines, including aspirins and ibuprofen containing products.

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Risperidone, sold zyprexa 300mg the brand name Risperdal among others, is an atypical antipsychotic 2 used to treat schizophrenia and bipolar disorder. Common side effects include severe depression, movement problems, sleepiness, dizziness, trouble seeing, constipation, and increased weight. Study of risperidone began in the late s and it was approved for sale in the United States in Risperidone is mainly used for the treatment of schizophrenia, bipolar disorder, and irritability associated with autism. Risperidone is effective in treating psychogenic polydipsia and the acute exacerbations of schizophrenia. Studies evaluating the utility of risperidone by mouth for maintenance therapy have reached varying conclusions.

Indicated for depressive episodes associated with bipolar I disorder in combination with fluoxetine. Safety of coadministered doses greater than olanzapine 18 mg with fluoxetine 75 mg have not been evaluated. Off-label use for prevention of chemotherapy associated nausea or vomiting in combination with 5-HT3 antagonist and dexamethasone N Engl J Med zyprexa 300mg Breakthrough nausea and vomiting: mg PO qDay for 3 days, when not used for acute and delayed emesis prevention. Safety of coadministered doses greater than olanzapine 12 mg with fluoxetine 50 mg have not been in pediatric clinical studies. Tardive dyskinesia may remit, partially or completely, if antipsychotic treatment withdrawn; however, antipsychotic treatment, itself, may suppress or partially suppress signs and symptoms of syndrome and possibly mask underlying process; effect symptomatic suppression has upon long-term course of syndrome unknown.

Anna K Morin; Off-label use of atypical antipsychotic agents for treatment of insomnia. Mental Health Clinician 1 March ; 4 2: 65— Metabolic adverse effects are particularly problematic with atypical antipsychotics, even at doses lower than those used to treat FDA-approved indications. The receptor affinity profiles of most atypical antipsychotic agents promote sedation. The zyprexa 300mg of H 1 -histamine receptor blockade is believed to be most associated with somnolence and sedation.

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