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The FDA does not verify the safety or effectiveness of compounded drugs. Only available if prescribed after an online consultation with a provider.
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- Major groups of drugs are discussed, with emphasis on areas of relevance to the three professions for whom the book is intended.
- Concurrent treatment with colchicine or a NSAID is necessary for the first three to six months.
- Elimination of lipid-soluble drugs is usually slow because clearance from plasma via the kidneys removes only a small proportion of the drug in any given time.
- Enkephalin is one of the endogenous endorphins, which are natural opioids.
- They block release of noradrenaline at sympathetic nerve endings and therefore cause vasodilation and reduced peripheral vascular resistance.
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Due to a reduction in vasoconstriction, this leads to a decrease in peripheral vascular resistance and blood pressure falls. Adverse effects, dry mouth, sedation and drowsiness, can be severe, limiting the usefulness of these two drugs. Adrenergic neurone blockers are used rarely to treat hypertension that is resistant to other drugs.
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These are a relatively recent development and act by increasing the efflux of potassium ions in smooth muscle cells of blood vessels. This leads to hyperpolarization of vascular smooth muscle thereby reducing the excitability and bringing about vasodilation. The resulting vasodilation in coronary arterioles improves blood flow to the myocardium. This, in combination with a reduction in both afterload and preload (dilation of veins), relieves the angina.
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