Introduction Patients with mild to moderate obstructive sleep apnoea OSA commonly suffer excessive daytime sleepiness. We hypothesised that modafinil may effectively treat sleepiness in untreated mild to moderate OSA. Mixed model analysis of variance was used to compare the changes on modafinil to placebo while classifying all randomised patients as random factors. The primary outcome ESS improved more on modafinil than placebo 3. Psychomotor Vigilance Task reciprocal reaction time improved significantly over placebo 0. Improvements on the Functional Outcomes of Sleep Questionnaire were not significant 5. Conclusions Modafinil significantly improved subjective sleepiness in patients with untreated mild to moderate OSA.

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