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High drug prices affect everyone—those who pay out-of-pocket, those with private insurance, and even those on Medicare Part D. Here are five instances in which medication prices are likely to be especially high, based on our analysis of drug-pricing data, and how you can avoid overspending. For example, the retail price of the bone-building drug Boniva ibandronate went up more than percent during the five years before it became available as a generic. One reason is that drug companies are producing fewer blockbuster treatments, says Stephen Schondelmeyer, Pharm. A result is that companies are milking the cash cow to get as much out of a drug as they can before it goes generic, he says.

Currently, the main classes of drugs used as potential cognitive enhancers include psychostimulants methylphenidate MPH, amphetamine, but wakefulness-promoting agents modafinil and glutamate activators ampakine are also frequently used. However, this enhancement likely comes with a neuronal, as well as ethical, cost. Furthermore, dopamine and norepinephrine do not display linear effects; instead, their modulation of cognitive and neuronal function maps on an inverted-U curve. Healthy individuals run the risk of pushing themselves beyond optimal levels into hyperdopaminergic and hypernoradrenergic states, thus vitiating the very behaviors they are striving to improve. Finally, recent studies have begun to highlight potential damaging effects of stimulant exposure in healthy juveniles. Humans have sought substances to improve our cognitive function for centuries, from ancient civilizations using hallucinogens in an attempt to raise their consciousness to commune with their gods, to the rise of coffee, to the more recent development of drugs such as stimulants and glutamate activators.

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