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Modafinil is a racemic substance with special abilities to enhance wakefulness; its mode of action seems to be different from those of other CNS stimulants. Modafinil appears to have a lower misuse liability than other regulated stimulants, while it is still a risk. In narcolepsy clinical studies, modafinil increased daytime vigilance as measured by reductions in the frequency and length of daytime sleep episodes. In clinical trials for narcolepsy, surveys of patient satisfaction found that modafinil reduces feelings of exhaustion and boosts mental alertness. The first new molecular entity to be used in treating narcolepsy in 20 years, modafinil Provigil was FDA-approved for use in individuals with the condition in December In children with narcolepsy, modafinil was no more beneficial than a placebo.

Researchers gave 64 healthy volunteers either modafinil or a placebo and asked them to complete a spoken language test. The drug is not without side effects, and has been associated with a risk of serious adverse effects, including psychiatric disorders and skin reactions. Drug regulators say that the benefits of modafinil only outweigh the risks for the treatment of narcolepsy. The study was carried out by researchers from the University of Cambridge, the University of Nottingham and Towson University. It was funded by the Wellcome Trust. By contrast, The Times' headline was spot on.

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