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Modafinil is an analeptic drug, prescribed for narcolepsy, obstructive sleep apnea and shift work disorder. Headache, nervousness, insomnia, agitation, confusion, personality disorders, tremor, anxiety; GI disturbances; hypertension, palpitations, tachycardia; angioedema; psychosis, depression, mania, abnormal LFTs. May increase metabolism of ciclosporin, oral contraceptives. The mechanism of modafinil is unknown but it appears to exert its stimulant effects by reducing GABA-mediated neurotransmission. Absorption: Well absorbed from the GI tract oral ; peak plasma concentrations after hr. Excretion: Mainly via urine History of psychosis, depression, mania.

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