Modafinil is an analeptic drug, prescribed for narcolepsy, obstructive sleep apnea and shift work disorder. Headache, nervousness, insomnia, agitation, confusion, personality disorders, tremor, anxiety; GI disturbances; hypertension, palpitations, tachycardia; angioedema; psychosis, depression, mania, abnormal LFTs. Uncontrolled moderate to severe hypertension or cardiac arrhythmias; history of left ventricular hypertrophy or ischaemic ECG changes, chest pain, any clinical signs of mitral valve prolapse. The mechanism of modafinil is unknown but it appears to exert its stimulant effects by reducing GABA-mediated neurotransmission. Absorption: Well absorbed from the GI tract oral ; peak plasma concentrations after hr. Excretion: Mainly via urine History of psychosis, depression, mania.

This medication is an analeptic drug, prescribed for narcolepsy, obstructive sleep apnea and shift work disorder. It is available as tablets to take by mouth at bed time. The usual dose is mg daily as a single morning dose or in 2 divided doses. Sleeplessness, nervousness, aggression, headache, loss of appetite, gastrointestinal disturbances, palpitations and rash. Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time.

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Provigil may be used alone or with other medications. Consideration should be given to the use of lower doses and close monitoring in geriatric patients see Use in Specific Populations. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction profile was similar across these studies. Clinical chemistry, hematology, and urinalysis parameters were monitored in the studies. No differences were apparent in alanine aminotransferase ALT, aspartate aminotransferase AST, total protein, albumin, or total bilirubin. Hematologic: agranulocytosis. Psychiatric disorders: psychomotor hyperactivity. Elimination of drugs that are substrates for CYP2C19 e.

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The Ministry of Public Health. International Health Regulations. Epidemiological Surveillance. National Tuberculosis Program. No Tobacco Control Program. Lebanon National Drugs Database.

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There is one patent protecting this compound. Modafinil has sixty-two patent family members in twenty-eight countries. There are twenty-six drug master file entries for modafinil. Nineteen suppliers are listed for this compound. There are four tentative approvals for this compound.

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