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The UK and US are throwing their weight behind research and development of these drugs in the hope to save more lives. During the pandemic, antivirals have been waiting in the wings for their moment while vaccines have been the superstars. One reason is that the development of these drugs has often been bumpy — or worse. But antivirals may be gaining ground as a treatment to combat COVID, especially now that some governments are providing cash — and three decades on, manufacturing processes have improved. It hasn't been an easy ride. First, the hype around hydroxychloroquine fizzled, compounded by warnings of links to psychiatric disorders. Taken together, the evidence to date points to an array of difficulties in developing effective antivirals, which are designed to halt viral replication in its tracks. Prime Minister Boris Johnson said recently. Scientists plan to test these drugs as a defense against infection before and after exposure, in environments such as care homes.

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In the EU, ivermectin tablets are approved for treating some parasitic worm infestations while ivermectin skin preparations are approved for treating skin conditions such as rosacea. Laboratory studies found that ivermectin could block replication of SARS-CoV-2 the virus that causes COVID, but at much higher ivermectin concentrations than those achieved with the currently authorised doses. Although ivermectin is generally well tolerated at doses authorised for other indications, side effects could increase with the much higher doses that ivermectin tablet buy europe be needed to obtain concentrations of ivermectin in the lungs that are effective against the virus. Toxicity when ivermectin is used at higher than approved doses therefore cannot be excluded. EMA therefore concluded that use of ivermectin for prevention or treatment of COVID cannot currently be recommended outside controlled clinical trials. Further well-designed, randomised studies are needed to draw conclusions as to whether the product is effective and safe in the prevention and treatment of COVID

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At least two states in India have turned to ivermectin to help manage their COVID outbreaks, even as experts warn against doing so. Goa, a tourist haven on India's west coast, and Uttarakhand, a northern state in the Himalayas, will use the anti-parasitic preventatively, giving it to wide swaths of their population in hopes of preventing future outbreaks. Leaders of both states said their recommendations were evidence-based. But the drug's efficacy for COVID has not been proven in a large randomized controlled trial, and no prominent health group -- the NIH and the WHO among them -- has recommended the drug in treatment or prophylaxis. Ivermectin should only be used in the context of a randomized controlled trial.

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