The misuse of tramadol has become a major aspect of the wider substance use challenge in recent years and is evolving into a health crisis at an alarming rate. However, literature on motivations for non-medical purpose tramadol use among commercial vehicle operators remains inadequate. The aim of this study was to document the motivations for non-medical purposes tramadol use in Kumasi. We conducted this exploratory qualitative study with 23 purposively selected commercial vehicle drivers 15 and assistants 8 in Kumasi, Ghana. Based on the findings of the study and the dependence and addictive potentials of tramadol, there is the need for psychoeducational programmes for persons who misuse tramadol and enhancement of operational capacities of regulatory agencies. However, misuse and dependence of tramadol, especially among the youth, manual workers, market women, commercial vehicle driversand students 4 in recent times has become a serious global issue in many countries, especially in Africa, Asia and Middle East 5, 6, 7, 8. In the US, statistics indicate that 3.

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