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ABSTRACT: The objective of this study was to develop competitive sustained release tablets of Tramadol Hydrochloride which releases the drug in a sustained manner, by using different polymers and study on there effect on release pattern. SR tablet of tramadol HCl dose mg were prepared by wet granulation, dry granulation, melt granulation and direct compression technique.

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Tramadol is a strong pain medication that is used to treat moderate to severe pain.

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The Ministry of Public Health.

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The Ministry of Public Health. International Health Regulations.

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Hydrocodone is a stronger opioid used to relieve severe pain. Opioids and narcotic pain medicines can lead to opioid use disorder.

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It is used to treat moderate to severe pain in adults.

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Ultram ER may be used alone or with other medications.

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The MHRA reminds healthcare professionals that opioids co-prescribed with benzodiazepines and benzodiazepine-like drugs can produce additive CNS depressant effects, thereby increasing the risk of sedation, respiratory depression, coma, and death. Healthcare professionals are advised to only co-prescribe if there is no alternative and, if necessary, the lowest possible doses should be given for the shortest duration.

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Tramadol is an opioid painkiller which is used for the treatment of moderate and strong pains by blocking the transmission of pain signals sent by nerves to the brains. Tramadol is a medicine which should not be used in mild pains.

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