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IV: Titrate dose to 10 mg or less immediately before procedure, not to exceed cumulative dose of 20 mg; reduce dose of narcotic by one third or omit, OR. Renal impairment: No dose adjustment recommended unless administered for prolonged period; decrease dose in prolonged periods. Orphan designations for management of acute repetitive seizures or for Dravet syndrome by various administrative routes eg, intranasal, buccal soluble film, or SC. Potentially toxic dose in patients 0. Due to long-acting metabolite, not considered a drug of choice in the elderly; associated with falls.
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