We hypothesize that a strategy that uses nebulisation of mucolytics or bronchodilators only on clinical indication not to be inferior to a strategy using preventive nebulisation of mucolytics or bronchodilators with regard to the number of ventilator free days in ICU patients at day Consecutive intubated and ventilated adult intensive care patients with an anticipated ventilation duration of minimal 24 hours will be recruited at ICU admission and onset of ventilation. Methods: Patients will be randomized to receive either: 'routine nebulisation', i. Nebulisation of bronchodilators in case of occurrence of bronchospasm and only when signs and symptoms of bronchospasm wheezing, increased airway pressures, increasing airway resistance, up sloping curve of de end tidal CO2 monitoring are confirmed. The decision to start nebulisation should be evaluated daily. In case the clinical indication no longer exists, the therapy should be stopped.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others; it may harm them, even if their symptoms are the same as yours. How to use Salbutamol Nebuliser Solution 4. You should tell your doctor if your asthma seems to be getting worse, or if this medicine stops working. You should not increase the dose without advice from your doctor. Pregnancy and breast-feeding and fertility Do not use Salbutamol Nebuliser Solution if you are in premature labour or have a threatened miscarriage. Do not breast-feed unless your doctor advises you to as salbutamol passes into breast milk.

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