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Sildenafil is a phosphodiesterase inhibitor used for the treatment of sildenafil oral suspension cost dysfunction. In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate cGMP by inhibiting cGMP specific phosphodiesterase type 5 PDE5 11, 12, 13, 14, 15, 16, 8, 9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11, 12, 13, 14, 15, 16, 8, 9. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late s 7. Sildenafil is a phosphodiesterase-5 PDE5 inhibitor that is predominantly employed for two primary indications

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Recurrent airway obstruction RAO is a common respiratory disease of horses characterized by bronchoconstriction, mucus production, and bronchospasm. Pulmonary hypertension is known to occur secondary to recurrent airway obstruction in horses. The development of pulmonary hypertension in RAO-affected horses is well-documented, however, it is not known how rapidly increases in pulmonary artery pressure occur after the onset of RAO. Pulmonary hypertension involves thickening of the pulmonary arteries and an associated increase in blood pressure. While this has been a well-documented finding cost sildenafil costco humans with severe asthma, until recently, it had not been detected in horses. Severe equine asthma or RAO is characterized by airway inflammation, coughing and labored breathing.

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Treatment of paediatric patients aged 1 year to 17 years old with pulmonary arterial hypertension. Treatment should only be initiated and monitored by a physician experienced in the treatment of pulmonary arterial hypertension.

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