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Sildenafil is a recognized treatment for patients suffering from erectile dysfunction and pulmonary hypertension. However, new evidence suggests that it may have a neuroprotective and a neurorestorative role in the central nervous system of both adults and neonates. Phosphodiesterase type 5—the target of sildenafil—is distributed in many cells throughout the body, including neurons and glial cells. Since its launch in, sildenafil has been used widely to treat erectile dysfunction ED for its recognized vasodilatatory and smooth muscle relaxant effects Giuliano et al. PDE5—the target of sildenafil—has been described as being present in neurons and glial cells astrocytes and microglias, as well as cerebrovascular endothelial cells both endothelial and smooth muscle cells Teich et al. Thus, PDE5 has gained increasing attention as a potential therapeutic target for several adult central nervous system diseases, including adult stroke Chen et al.

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