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Rheumatic diseases are a group of chronic inflammatory diseases that include rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus and psoriatic arthritis. As a group they are characterized by increased activity of phagocytes and the release of inflammatory mediators, which cause tissue damage. In diseases that primarily affect the joints there is inflammation and proliferation of cells of the synovial membrane and damage to cartilage and bone, but other connective tissues and organs in the body can also be damaged. Rheumatoid arthritis is a chronic inflammatory autoimmune disease of largely unknown aetiology affecting about than men. It is diagnosed after persistent symmetrical multiple joint inflammation of more than six weeks duration.
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The first three of these require a working partnership with medically qualified professionals; the last two do not. Two sections presented here have been written by practitioners in podiatry and radiography.
- The lipid theory states that general anaesthetics interact with lipids in the neuronal cell membrane and disrupt neurotransmission and the protein theory states that general anaesthetics interact with membrane proteins to alter release of neurotransmitters.
- Particle size is a major determinant of absorption from this site of administration.
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- Patients must not be taking other photosensitizing drugs, for example phenothiazines and benzodiazepines, NSAIDs and some antibiotics.
- Lubricants work by coating the faeces and rectal wall, thereby aiding expulsion of faeces.
- However, specialist individual therapy is essential for maximum benefit to the patient and avoidance of the development of resistant strains of bacteria.
In addition to this, many older patients use self-medication with non-prescribed remedies. It has been estimated that on average, for each prescription item older people receive, they use two additional non-prescription items.
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Difficulty in walking with sensory disturbances is a sign of spinal cord lesions. Typically the disease affects young people between relapses interspersed with variable periods of remission.
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These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes). The immediate effects are due principally to the action of histamine and include hyper-responsiveness and constriction of bronchial smooth muscle and inflammation of bronchial epithelium. Both of these effects combine to produce an increase in airway resistance, that is, a narrowing of the airway and difficulty breathing out. Other symptoms are wheezing and coughing. Patients usually describe the sensation as like having a tight band around the chest limiting the movement of the thorax.
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Adverse effects of fluorouracil are less likely, but similar to methotrexate. Cytarabine is a pyrimidine analogue, which is incorporated into both RNA and DNA and interferes with the action of DNA polymerase. Cytarabine is used to treat leukaemia. Adverse effects of cytarabine are bone marrow suppression and gastrointestinal disturbances. Some cytotoxic antibiotics prevent cell division by direct action on DNA.

As air passes through the nasal passages it is also warmed and moistened. The epiglottis is a flap of cartilage that closes the trachea during swallowing. The larynx is sildenafil vegah extra 130 mg jaguar in the pharynx at the top of the trachea. It contains membranes called vocal cords, which vibrate when air passes over them to produce sounds, thus allowing speech. The trachea is a short tube supported by incomplete rings of cartilage, which keep the trachea open despite pressure changes that occur during breathing and prevent kinking when the head is turned.
Authored by Robert Benjamin Meade, OD
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