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If the NaK ATPase pump is inhibited, the concentration of sodium ions in the cell increases reducing the concentration gradient for exchange with calcium ions. Thus, the concentration of calcium ions within the cell rises. The effect of increased intracellular calcium ion levels is a more controlled forceful contraction of the myocardium. This is known as a positive inotropic effect. In addition, through an effect in the central nervous system cardiac glycosides cause an increase in parasympathetic activity and therefore slow conduction through the AV node, hence their usefulness in atrial flutter and atrial fibrillation.
Premedication is the use of drugs to reduce a patients anxiety and to prevent parasympathetic effects of the anaesthetic. Muscle relaxants and analgesics are used as adjuncts to anaesthesia, respectively to cause muscle relaxation and aid surgery and to reduce patient discomfort post-operatively. Local anaesthetics are also known as local analgesics because they cause the loss of the sensation of pain in a part of the body.
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Carrier proteins are involved in the transport of many molecules across cell membranes. Neurotransmitter carrier mechanisms are of particular interest since many drugs have been developed that interfere with this process. Carrier proteins can be inhibited by drugs or persuaded to pick up false transmitters. For example, selective serotonin reuptake inhibitors inhibit membrane carriers for serotonin, and methyldopa is taken up into neurons by cheap kamagra jelly carrier for dopa and subsequently converted to the false transmitter methylnoradrenaline. Enzymes are the targets for many drugs.
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Beta blockers are used to treat ischaemic heart disease, arrhythmia and hypertension.
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Some cytotoxic antibiotics prevent cell division by direct action on DNA.
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Biventricular failure often follows left ventricular failure and consequently oedema develops in the peripheral tissues, causing swelling of the legs, and in the lungs, causing breathlessness.
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For example, general anaesthetics are highly lipid-soluble drugs.
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