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Clinical studies of REVATIO did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy see Clinical Pharmacology No dose adjustment for mild to moderate impairment is required.

Severe impairment has not been studied see Clinical Pharmacology In studies with healthy volunteers of single doses up to mg, adverse events were similar to those seen at lower doses but rates and severities were increased. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine. Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.

Each tablet contains sildenafil citrate equivalent to 20 mg of sildenafil. Each mL of solution contains 1. The inactive ingredients include sorbitol, citric acid anhydrous, sucralose, sodium citrate dihydrate, xanthan gum, titanium dioxide, sodium benzoate, colloidal silicon dioxide anhydrous and grape flavor. In addition to the bottle, a press-in bottle adapter and an oral dosing syringe with 0.

Sildenafil, therefore, increases cGMP within pulmonary vascular smooth muscle cells resulting in relaxation.

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