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Sildenafil citrate Viagra is a phosphodiesterase PDE 5A inhibitor commonly used for erectile dysfunction. Objective To evaluate the association between sildenafil use and risk of incident melanoma among men in the United States. Design, Setting, and Participants Our study is a prospective cohort study. Recent sildenafil use at baseline was significantly associated with an increased risk of subsequent melanoma with a multivariate-adjusted hazard ratio HR of 1. Moreover, erectile function itself was not associated with an altered risk of melanoma.

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