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There may be reduced phosphorylation of the drug, alteration of viral enzyme targets, or alteration of target channel protein. These synthetic compounds resemble the natural nucleotides of viral DNA or RNA. They are phosphorylated in infected cells and then compete with the normal nucleotides for incorporation into viral DNA or RNA. This results in irreversible inhibition of viral polymerase.

See Figure for a diagram of a nucleotide. ) Aciclovir is an analogue of guanosine nucleoside. It is used to treat herpes infections. Side effects of topical acyclovir are rare. Use of the drug intravenously to treat systemic herpes can cause nausea and headache and possibly kidney damage.

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Figure Chylomicrons are the largest lipoproteins and they transport lipids and cholesterol absorbed from the small intestine to the liver. The liver can synthesize cholesterol if there is not enough in the diet. Very low-density lipoproteins are smaller than chylomicrons but still relatively large.

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