Opening of the channel allows chloride ion flux to hyperpolarize the neuron and, consequently, enables GABAergic neurons to produce a larger inhibitory effect. Diagram of mechanism of action of the natural neurotransmitter GABA gamma-aminobutyric acid and benzodiazepines on nerve cells neurons in the brain 2. Mechanism of action of the natural neurotransmitter GABA gamma-aminobutyric acid and benzodiazepines on nerve cells neurons in the brain. An analysis was conducted to evaluate the speed of onset of action of both treatments. Primary efficacy measures were the Sheehan Panic Disorder Scale and the item clinician-rated global improvement scale. Patients were required to keep a diary of their medications, panic attacks, and limited symptom attacks.

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