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The elimination half-life is how long it takes for half of the drug to be eliminated by the body. Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce active metabolites. Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and chlordiazepoxide, are often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for insomnia due to their lesser hangover effect. It is fairly important to note that elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Individuals with an impaired liver also metabolize benzodiazepines more slowly. Thus, the approximate equivalent of doses below may need to be adjusted accordingly in individuals on short acting benzodiazepines who metabolize long-acting benzodiazepines more slowly and vice versa. The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms. Data in the table below is taken from the Ashton Benzodiazepine Equivalency Table.

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He was apathetic — and occasionally violent. He could feel his personality changing. Brad decided to quit cold turkey. Withdrawal from benzodiazepines — the family of drugs to which Xanax belongs — can be life-threatening, so he knew it was alprazolam 2mg india to be difficult. But he was still unprepared for his first seizure, a week and a half later. Officially, Xanax barely exists in the UK.

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Take Alprazolam exactly as directed by your doctor. Do not take more or less than instructed by your doctor. Do not take Alprazolam for a longer period of time than instructed by your doctor. In some medical conditions, such as anxiety, panic attacks and insomnia, it is not advisable to take Alprazolam long-term. See your doctor if Alprazolam does not seem to help you. If you are taking Alprazolam as a sleeping pill, you should take it only when you have problems sleeping and when you are able to sleep for hours without being interrupted.

Clonazepam, sold under the brand Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and the movement disorder known as akathisia. Common side effects include sleepiness, poor coordination, and agitation. Clonazepam was patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short term management of epilepsy and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam.

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