The MHRA reminds healthcare professionals that benzodiazepines and benzodiazepine-like drugs co-prescribed with opioids can produce additive CNS depressant effects, thereby increasing the risk of sedation, respiratory depression, coma, and death. Healthcare professionals are advised to only co-prescribe if there is no alternative and, if necessary, the lowest possible doses should be given for the shortest duration. Patients should be closely monitored for signs of respiratory depression at initiation of treatment and when there is any change in prescribing, such as dose adjustments or new interactions. If methadone is co-prescribed with a benzodiazepine or benzodiazepine-like drug, the respiratory depressant effect of methadone may be delayed; patients should be monitored for at least 2 weeks after initiation or changes in prescribing. Acute pulmonary insufficiency; marked neuromuscular respiratory weakness; not for use alone to treat chronic psychosis; not for use alone to treat depression or anxiety associated with depression ; obsessional states; phobic states; sleep apnoea syndrome; unstable myasthenia gravis.

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Statistical Methods: FDA bioequivalence statistical methods. Drug: Alprazolam Extended-Release 3 mg Tablets 1 x 3 mg, single dose non-fasting.

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Alprazolam is a benzodiazepine. It works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain and induces sleep. Melatonin is a natural hormone which helps to regulate the sleep-wake cycle. Zobara Alkem Laboratories Ltd. Alprax Z Torrent Pharmaceuticals Ltd.

Or in a crisis, text NAMI to All FDA black box barnings are at the end of this fact sheet. Alprazolam is a benzodiazepine. It is approved for the treatment of generalized anxiety disorder GAD and panic disorder with or without agoraphobia. However, benzodiazepines are also commonly used to treat difficulty sleeping and alcohol withdrawal.

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It is used for the short-term symptomatic relief of excessive anxiety. It is also used to treat generalized anxiety disorder and panic disorder. Alprazolam works by slowing down the brain central nervous system. Mylan-Alpraz is no longer being manufactured for sale in Canada. For brands that may still be available, alprazolam 3mg under alprazolam.

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