The health emergency triggered by the COVID pandemic has led to the massive use of pharmacological treatments whose efficacy has not been sufficiently evidenced. One of the most widely used drugs in the treatment of COVID has been azithromycin, since it has known antiviral properties and immunomodulatory effects, from which benefits have been obtained in the treatment of other respiratory diseases. The ATOMIC2 study by Timothy Hinks and colleagues recruited patients whose symptoms brought them to the emergency room, where they were diagnosed with COVID, but whose condition was not considered serious enough to be admitted participant age was Therefore, the study focuses on a specific stage in the evolution of COVID, of intermediate severity, which is not well represented in previous studies with patients admitted to hospital, not in the principal study, which recruited patients diagnosed in primary care. Nor did the two previous trials that tested efficacy demonstrate clinical benefits of azithromycin, in combination with the hydroxychloroquine, in patients seen outside the hospital. Obtaining a PCR test result in patients not admitted to hospital is especially difficult, given that the test was unavailable at some points during the epidemic, given the waiting times that have often been necessary to obtain results of the tests outside the hospital. On the one hand, limiting the analyses to patients with positive PCR results would have caused the exclusion of a large number of patients who actually had COVID but did not have a PCR test, or had falsely negative results.

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Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with the latter also having in vitro antiviral properties. Methods Placebo-controlled double-blind randomised multicentre trial. The primary outcome was days alive and discharged from hospital within 14 days DAOH Results After randomisation of patients, at the first planned interim analysis, the data and safety monitoring board recommended stopping enrolment due to futility, based on pre-specified criteria. Consequently, the trial was terminated on 1 February In the intervention group, patients had a median interquartile range 9. Conclusions The combination of azithromycin and hydroxychloroquine did not improve survival or length of hospitalisation in patients with COVID

Trials volume 22, Article number: Cite this article. Azithromycin is a macrolide antibiotic, known for its immunomodulatory properties. Patients hospitalized on dedicated COVID wards are eligible for study inclusion when they are symptomatic i. Patients are block-randomized 9 patients with a allocation to receive azithromycin plus standard of care versus standard of care alone. The trial investigates the urgent and still unmet global need for drugs that may impact the disease course of COVID

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Azithromycin tablets come as either mg or mg strengths. The liquid comes as mg in 5ml. The usual dose is mg a day for 3 to 10 days depending on the infection being treated. The dose may be lower for children or if you have liver or kidney problems. Azithromycin is sometimes prescribed long-term to prevent chest infections if you keep getting them. In this case you will usually need to take it 3 times a week, often on a Monday, Wednesday and Friday.

Antibiotics are cheap and common medicines used to treat bacterial infections. In laboratory tests, one antibiotic, azithromycin, reduced viral activity and inflammation, and so it has been studied as a potential treatment for COVID We wanted to know if antibiotics reduce death, severity of disease, and length of infection in people with COVID, if they have an effect on quality of life or cause unwanted effects. We included studies that compared antibiotics to placebo dummy treatment, no treatment, usual care, another antibiotic, or treatments for COVID that are known to work to some extent, such as remdesivir or dexamethasone. We excluded treatments that we know do not work for COVID, such as hydroxychloroquine, or have an unknown influence on the disease. We searched for studies that investigated antibiotics to treat people with COVID in hospital or as outpatients.

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However, a recent study from the UK confirmed that adding azithromycin to standard care treatment of patients with mild-to-moderate COVID diagnosis was not associated with reduced subsequent hospital admissions or death, or duration of hospital stays. The antibiotic was among those in its drug class to be considered for treatment of the pandemic virus in early, according to investigators led by Timothy Hinks, MD, Wellcome Trust Career Development Fellow, Respiratory Immunology, Nuffield Dept of Medicine. However, the antibiotic did have antiviral and anti-inflammatory properties that were beneficial to early-stage management of various diseases, which prompted researchers to establish whether it also averts disease progression in patients with COVID The team studied and ambulatory population of patients. Patients were recruited into the study from June 3, to January 29,

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We assessed the impact of the coronavirus disease COVID epidemic in India on the consumption of antibiotics and hydroxychloroquine HCQ in the private sector in compared to the expected level of use had the epidemic not occurred. A total of 16, million doses of antibiotics were sold in India in, which is slightly less than the amount in and However, the proportion of non-CAF antibiotics increased from Study limitations include the lack of coverage of the public healthcare sector, the inability to distinguish antibiotic and HCQ sales in inpatient versus outpatient care, and the suboptimal number of pre- and post-epidemic data points, which could have prevented an accurate adjustment for seasonal trends despite the robustness of our statistical approaches. A significant increase in non-CAF antibiotic sales, and particularly azithromycin, occurred during the peak phase of the first COVID epidemic wave in India, indicating the need for urgent antibiotic stewardship measures.

The oral tablet is available as a generic drug as well as the brand-name drug Zithromax. Azithromycin is used to treat infections caused by certain bacteria. The drug should not be used to treat infections caused by viruses, such as the common cold. Azithromycin works by stopping bacteria from multiplying making more bacteria. This action kills the bacteria and treats your infection.

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