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Sertraline, marketed under the brand name Zoloft, is indicated for the treatment of conditions such as major depressive disorder, obsessive-compulsive disorder and social anxiety disorder. Sertraline works by inhibiting the reuptake of serotonin 5-HT - a chemical neurotransmitter - by neurons in the central nervous system. Serotonin has been seen to have effects on one's mood, sleep, anxiety and sexual behavior among other things and sertraline medication is thought to work by potentiating its activity. Depending on the prescriber's judgment, the initial dose of sertraline is often 25 mg or 50 mg per day.

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