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Wellbutrin is a medication prescribed to some patients with major depressive disorder. Wellbutrin is different from selective serotonin reuptake inhibitor medications SSRIs such as citalopram Celexa and sertraline Zoloft in that it belongs to a drug class known as norepinephrine-dopamine reuptake inhibitors NDRIs. Wellbutrin contains the active ingredient bupropion hydrochloride. It is not exactly clear how Wellbutrin exerts its effects. However, Wellbutrin may have a mechanism of action involving inhibition or activity on the neurotransmitters norepinephrine, dopamine and serotonin.

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