All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Some patients who stopped smoking may have been experiencing symptoms of nicotine withdrawal, including depressed mood. However, some of these adverse events occurred in patients taking bupropion who continued to smoke. Neuropsychiatric adverse events occurred in patients without and with pre-existing psychiatric disease; some patients experienced worsening of their psychiatric illnesses. Observe patients for the occurrence of neuropsychiatric adverse events.

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These costs are decided by your employer or health plan. Lists may change over time and some medications listed may not be covered by your specific plan. If you are a member of one of these groups Eligible Organizations, UnitedHealthcare is required to cover certain birth control products and services at no cost to you. The below lists contain preventive medications that may be covered under your plan. If your plan has one of these lists, your insurance benefit may be applied before you meet your deductible for the listed preventive medications.

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Action Exact mechanism of antidepressant activity or as a smoking deterrent unknown; does not inhibit monoamine oxidase. Indications Treatment of depression; aid to smoking cessation treatment. Contraindications Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa; concurrent treatment with or within 14 days of discontinuation of MAO inhibitors; concurrent treatment with multiple bupropion products eg, coadministration of Zyban for smoking cessation and Wellbutrin for depression ; abrupt discontinuation of alcohol or sedatives. Initiate treatment while patient is still smoking. Patient should set target date to quit smoking within the first 2 wk of treatment; continue treatment for 7 to 12 wk.

This medication is used to treat depression. It may also be used to prevent seasonal affective disorder SAD, a type of depression that occurs each year at the same time for example, during winter. This medication can improve your mood and feelings of well-being. It may work by restoring the balance of certain natural substances dopamine, norepinephrine in the brain. If you have any questions, ask your doctor or pharmacist.

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Safety concerns with bupropion include depression, hypertension, and risk of seizures, whereas acute opioid withdrawal and opioid overuse have been associated with naltrexone. However, clinical trials of the combination compared with placebo found no increase in depression and no increase in suicidality. Because it may raise blood pressure and heart rate, it should not be used in patients with uncontrolled high blood pressure. Although one of the goals of weight loss is to decrease the risk of cardiovascular outcomes, patients with active cardiovascular disease, including significant heart failure, history of myocardial infarction, angina, or stroke, were excluded from premarketing studies. A large cardiovascular outcomes study that includes these patients is now ongoing. Bupropion is metabolized in the liver and its use may increase serum levels of some antidepressants, antipsychotics, beta blockers, and antiarrhythmics.

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