Objectives Many people with type 2 diabetes experience clinical inertia, remaining in poor glycaemic control on oral glucose-lowering medications rather than intensifying treatment with a glucagon-like peptide-1 receptor agonist, despite an efficacious, orally administered option, oral semaglutide, being available. Interventions Modelled patients received oral semaglutide immediately in the first year of the analysis or after a 2-year delay, after which all physiological parameters were brought to values observed in the immediate therapy arm. During the simulation, patients intensified with the addition of basal insulin and, subsequently, by switching to basal-bolus insulin. Results Immediate oral semaglutide therapy was associated with improvements in life expectancy of 0. Immediate oral semaglutide therapy was therefore associated with an incremental cost-effectiveness ratio of GBP to 10 per QALY gained versus a 2-year delay. Data are available upon reasonable request. All original data generated during this study are available from the corresponding author on reasonable request.

For example, when it comes to spending on Type 2 diabetes drugs by private insurance plans in Canada, 30 per cent of the time doctors prescribed vastly more expensive drugs without first trying cheaper alternatives. Spending on diabetes drugs is growing faster than any other category of drugs in Canada, according to health-care data company IMS Health. It's a lot of money that could be used for other things in the health-care system. In Canada, doctors often rely on the drug companies to teach them about new drugs and their potential benefits, a situation that inevitably creates a conflict of interest, experts say. A drug company will likely favour its own products, even if they are not the best or cheapest option. One of the ways drug companies market their products to doctors is sponsoring booths at medical education conferences. In all cases, the drug representatives used a tactic experts consider questionable.

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The Ministry of Public Health. International Health Regulations. Epidemiological Surveillance. National Tuberculosis Program. No Tobacco Control Program. Lebanon National Drugs Database. Expanded Program on Immunization. Local Manufacturing Industries. Pharmacovigilance System in Lebanon.

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