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The availability of generics allows for generics substitution reducing the cost of treatment. However, only generics that offer similar bioavailability with the originator should be considered. Blood samples were collected 0, 0. Nine generics met the quality assessment standards and the in vivo bioequivalence study was achieved in 17 healthy volunteers.

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Yeast infection of the penis. Low vitamin B 12 vitamin B 12 deficiency. Ketoacidosis is a serious condition, which needs to be treated in the hospital. Swelling of an uncircumcised penis may develop that makes it difficult to pull back the skin around the tip of the penis. Low blood sugar hypoglycemia. Tell your healthcare provider if you have symptoms of a urinary tract infection, such as a burning feeling when passing urine, a need to urinate often or right away, pain in the lower part of your stomach or pelvis, or blood in the urine.

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Serious urinary tract infections. It may increase their risk of diabetic ketoacidosis increased ketones in the blood or urine. Your healthcare provider may do blood tests to check your vitamin B 12 levels. This can increase your chance of getting pregnant. The dose of your sulfonylurea medicine or insulin may need to be lowered. Ketoacidosis increased ketones in your blood or urine.

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Adjunctive therapy to diet and exercise to improve glycemic control in adults with type 2 diabetes. Elderly patients are more likely to have decreased renal function; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases. Concomitant administration of insulin and insulin secretagogues e. Withholding of food and fluids during surgical or other procedures may increase risk for volume depletion, hypotension, and renal impairment; therapy should be temporarily discontinued while patients have restricted food and fluid intake. Decreases hepatic glucose production; decreases GI glucose absorption; increases target cell insulin sensitivity.

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