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Ebixa will also be made available on the National Health Service, albeit in a more restricted setting. With up to, people suffering from AD in England and Wales, the impact of this guidance is expected to be significant. S, Reminyl galantamine; Shire Pharmaceuticals, U. The cost watchdog has today issued a new appraisal consultation document ACD, which states that acetylcholinesterase AChE inhibitors Aricept, Reminyl, and Exelon are recommended for the treatment of mild-to-moderate AD, subject to several conditions NICE has also recommended the use of Ebixa for the treatment of moderate or severe AD in patients who are intolerant of or have a contraindication to AChE inhibitors, provided that the same conditions attached to the use of the AChE inhibitors with the exception of the fourth condition are met.

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As a result, local policies were introduced from the start that restricted prescribing of donepezil. Pre-NICE, the Standing Medical Advisory Committee recommended that donepezil should be initiated and supervised by a specialist experienced in dementia, that benefits should be assessed at 12 aricept prices uk and that treatment should only be continued for patients with evidence of benefit. As long-term care is a much more distant prospect for people with mild dementia than with moderate disease, it was much harder to demonstrate beneficial effects of the drugs in mild disease. Donepezil was discovered in the Japanese laboratories of Eisai Co Ltd. Eisai failed to develop a non-toxic tacrine derivative, but random screening threw up an N-benzylpiperazine derivative with anti-AChE activity in rat brain. The initial compound was weak but, from the approximately derivatives that were synthesised, the inandone derivative donepezil struck the right balance of anti-AChE activity and duration of action.

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