Tamsulosin is a competitive alpha-1 adrenoceptor antagonist with some selectivity for alpha-1A and alpha-1D relative to alpha-1B adrenoceptor subtypes. From: Reference Module in Biomedical Sciences, The selectivity of this compound for the prostate is reflected in the fact that there is little decrease in blood pressure after therapeutic doses of the drug. Tamsulosin is well absorbed after oral administration and circulates tightly bound to plasma proteins. It is extensively metabolized in the liver and excreted as inactive conjugation products in the urine. Michel, in Reference Module in Biomedical Sciences, Tamsulosin undergoes extensive hepatic metabolism, with its metabolites excreted primarily in urine.

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BPH refers to the enlargement of prostate gland that occurs most commonly in elderly males. After the age of 50, most men develop enlarged prostates. Since, the prostate gland is located below the bladder; its enlargement causes restriction of urine flow. This can lead to lower urinary tract symptoms LUTS such as: Interruption of sleep frequently caused by a need to urinate Weak urinary stream A sensation of not emptying the bladder completely after finishing urination Pushing or straining to start urination Stopping and starting several times while urinating Urinating again within 2 hours of finishing urination Finding it difficult to postpone urination How Does Flomax Work? Flomax tamsulosin hydrochloride is an alpha receptor blocking agent. Is There a Generic Equivalent of Flomax?

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The disease is developed as a purchase flomax of the glandular tissue growth and may cause an acute urinary retention. BPH is a benign neoplasm, it means that it does not cause metastasis. But in case of the neglected treatment, a man may have a dysfunction of kidneys and urinary bladder, and renal failure. Blood in urine, severe edema, and acute pain in kidneys are bad symptoms. Flomax copes with the symptoms of the disease and prevent the growth of the glandular tissue.

Flomax, containing the active ingredient tamsulosin hydrochloride, belongs to a class of medications known as alpha 1 adrenoceptor antagonist medications. Flomax exerts its effects selectively on receptors in the prostate gland known as alpha 1 receptors. These adrenoceptors are involved with the tensing up and relaxation of smooth muscle in the prostate and the neck of the bladder. By blocking these receptors, Flomax helps to relax these muscles, both reducing symptoms that may occur from prostate enlargement and improving the flow of urine and urine output. Given these effects, Flomax is used to treat people with symptoms resulting from BPH. Flomax is similar to the medications alfuzosin UroXatral, doxazosin Cardura and silodosin Rapaflo.

A significant proportion of men suffer from lower urinary tract symptoms LUTS secondary to prostatic enlargement. If medical management of BPH fails surgical transurethral resection of the prostate maybe required. The continuation of pharmacological therapy post operatively is redundant, however it was noted that several patients remained on these medications post TURP. Of the 89 men, only 46 were given a clear instruction to stop these drugs on discharge. Continuation of the above medication is unnecessary post TURPs with potentially avoidable side effects for patients and an unnecessary expense.

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