Cilostazol, a phosphodiesterase III inhibitor, is indicated to treat the symptoms of intermittent claudication and increase walking distance in patients with peripheral arterial disease PAD. At the time of approval, the United States Food and Drug Administration required an additional long-term safety study to evaluate the effect cilostazol on mortality. A total of subjects with a clinical diagnosis of PAD and symptoms of claudication were screened for participation in a randomized, double-blinded, placebo-controlled safety study of cilostazol. A total of patients received cilostazol and received placebo. Cilostazol was administered at a primary dose of mg twice daily.

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Cilostazol Pletal, a quinolinone derivative, has been approved in the U. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 PDE3 and subsequent elevation of intracellular cAMP levels. Recent preclinical studies have demonstrated that cilostazol also possesses the ability to inhibit adenosine uptake, a property that may distinguish it from other PDE3 inhibitors, such as milrinone. Elevation of interstitial and circulating adenosine levels by cilostazol has been found to potentiate the cAMP-elevating effect of PDE3 inhibition in platelets and smooth muscle, thereby augmenting antiplatelet and vasodilatory effects of the drug. One, or a combination of several of these effects may contribute to the clinical benefits and safety of this drug in IC and other disease conditions secondary to atherosclerosis. In addition, cilostazol improved quality of life indices as assessed by patient questionnaire. Cilostazol has been generally well-tolerated, with the most common adverse events being headache, diarrhea, abnormal stools and dizziness. Frequently asked questions. My Bibliography Add to Bibliography. Generate a file for use with external citation management software.

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Medications similar to cilostazol caused an increased risk of death in patients buy pletal cilostazol congestive heart failure condition in which the heart is unable to pump enough blood to the other parts of the body. Tell your doctor if you have or have ever had congestive heart failure. Your doctor will probably tell you not to take cilostazol. Cilostazol is used to reduce the symptoms of intermittent claudication pain in the legs that worsens when walking and improves when resting that is caused by narrowing of the blood vessels that supply blood to the legs. It works by improving blood flow to the legs.

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Indications Cilostazol is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increase in walking distance. Dosage The bought pletal cilostazol dose of cilostazol is mg twice daily taken one-half hour before meals or two hours after meals. Patients taking inhibitors of cytochrome P 3A4, such as ketoconazole, itraconazole, erythromycin, or diltiazem, should undergo initial therapy with 50 mg twice of cilostazol. Grapefruit juice should be avoided as it can also inhibit 3A4. Potential Disadvantages Cilostazol is contraindicated in patients with congestive heart failure.

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