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Refer to the leaflet for more details. These can manifest in feelings of irritability, difficulty sleeping, an increased appetite, or in a range of other ways; which can make smoking a difficult habit to stop. Depression, anxiety, agitation, lack of concentration, tremors, headache, nausea and vomiting, stomach pain, constipation, dry mouth, fever, dizziness, sweating, skin rash or irritation, itching. This constituent inhibits the reuptake of two chemicals, noradrenaline and dopamine, which act as mood regulators.

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Antidepressants are a type of medicine used to treat clinical depression. Antidepressants are also sometimes used to treat people with long-term chronic pain. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion. Neurotransmitters may also affect pain signals sent by nerves, which may explain why some antidepressants can help relieve long-term pain.

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