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Effect of non-steroidal anti-inflammatory drug etoricoxib on the hematological parameters and enzymes of colon and kidney. However, the drug treatment at both the dose level produced significant fall in the activities of alkaline phosphatase, sucrase, lactase and maltase in the kidney but increased the activity of alkaline phosphatase in colon. The treatment of etoricoxib did not produce any change in the nitric oxide and citrulline levels in kidney while an increase was noted in the colonic tissue. It was concluded that etoricoxib is a relatively safe drug at its anti-inflammatory ED50 dose in rats when the hematological parameters and the structural and functional characteristics of kidney and colonic tissues were studied.

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Currently it is approved in more than 80 countries worldwide but not in the US, where the Food and Drug Administration FDA has required additional safety and efficacy data for etoricoxib before it will issue approval. It was patented in and approved for medical use in Etoricoxib is indicated for the treatment of rheumatoid arthritis, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain, and gout. Approved indications differ by country. Among the different functions exerted by PGs, their role in the inflammation cascade should be highlighted. Because of these results, some drugs were withdrawn from the market rofecoxib in September and valdecoxib in April

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