Common side effects include menstrual disturbances such as absence of periods, abdominal pain, and headaches. Due to its progestogenic activity, MPA decreases the body's release of gonadotropins and can suppress sex hormone levels. MPA was discovered in and was introduced for medical use in the United States in It is an extremely effective contraceptive when used with relatively high doses to prevent ovulation. MPA is also used in combination with an estrogen in menopausal hormone therapy in postmenopausal women to treat and prevent menopausal symptoms such as hot flashes, vaginal atrophy, and osteoporosis. Though not used as a treatment for epilepsy, MPA has been found to reduce the frequency of seizures and does not interact with antiepileptic medications. MPA does not interfere with blood clotting and appears to improve blood parameters for women with sickle cell anemia.

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Medroxyprogesterone acetate is a type of hormonal therapy drug to treat womb, kidney, and breast cancer. Medroxyprogesterone is also occasionally used as a treatment for poor appetite. Your doctor may suggest that you take it if you are losing weight because it can help to boost your appetite. Progestogens act like progesterone, which is a sex hormone. Hormones are natural substances made by glands in our bodies. They are carried around our body in our bloodstream and act as messengers between one part of our body and another.

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