You should not use divalproex sodium if you have liver disease, a urea cycle disorder, or a genetic disorder such as Alpers' disease or Alpers-Huttenlocher syndrome. What other drugs will affect divalproex sodium? Search the Healthwise Knowledgebase. You should not use divalproex sodium if you are allergic to it, or if you have: liver disease; a urea cycle disorder; or a genetic mitochondrial MYE-toe-KON-dree-al disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old. Tell your doctor if you have ever had: liver problems caused by a genetic mitochondrial disorder; depression, mental illness, or suicidal thoughts or actions; or a family history of a urea cycle disorder or infant deaths with unknown cause.

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It's thought to work by increasing the amount or mimicking the action of a neurotransmitter, GABA, in the brain, but the exact mechanism is unknown. Increasing levels of GABA may help prevent brain signals that lead to seizures. It was approved to treat bipolar disorder in, and in it was approved for use as a migraine prevention medication. Abbot Laboratories manufactures Depakote. In, Abbot Laboratories pleaded guilty to federal charges for marketing Depakote as a drug to control agitation and aggression in elderly nursing home patients. The FDA requires Depakote to carry a black-box warning because it can cause serious liver damage that could be fatal, especially in children younger than 2.

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Divalproex sodium oral tablet is available as the brand-name drugs Depakote delayed release and Depakote ER extended release. Divalproex sodium may be used as part of a combination therapy. That means you may need to take it with other drugs. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

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Hepatic failure resulting in fatalities has occurred in patients receiving valproate and its derivatives. When Depakote is used in this depakote 5 mg group, it should be used with extreme caution and as a sole agent. This older group of patients should be closely monitored during treatment with Depakote for the development of acute liver injury with regular clinical assessments and serum liver testing. Depakote tablets are for oral administration. Depakote tablets are supplied in three dosage strengths containing divalproex sodium equivalent to mg, mg, or mg of valproic acid.

Divalproex sodium, valproate sodium, and valproic acid, are all similar medications that are used by the body as valproic acid. Therefore, the term valproic acid will be used to represent all of these medications in this discussion. Valproic acid may cause serious or life-threatening damage to the liver that is most likely to occur within the first 6 months of therapy. The risk of developing liver damage is greater in children who are younger than 2 years of age and are also taking more than one medication to prevent seizures, have certain inherited diseases that may prevent the body from changing food to energy normally, or any condition that affects the ability to think, learn, and understand. Tell your doctor if you have a certain inherited condition that affects the brain, muscles, nerves, and liver Alpers Zyprexa zydis buy Syndrome, urea cycle disorder an inherited condition that affects the ability to metabolize protein, or liver disease.

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The ER stands for extended-release, which means that the time it takes the pills to dissolve and release the medicine is longer. Most people need to take regular Depakote two, three, or even four times a day because the pills release all their medicine within a few hours. It's hard to remember to take pills that often. Depakote ER is designed so that the pills can be taken only once a day. So it's a lot easier depakote 5 mg remember and more convenient.

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It comes as oral tablets and oral capsules. The active ingredient in Depakote and Depakote ER is divalproex sodium. For a comprehensive look at Depakote and Depakote ER, see this article. DR tablets have a special coating that stops the tablet from dissolving too soon while in the stomach. ER tablets release the drug slowly over 24 hours. With sprinkle capsules, you can swallow the capsules whole or open the capsules and sprinkle the medication onto food.

Valproate-containing medicines have been approved nationally in the EU to treat epilepsy and bipolar disorder and in some countries for prevention of migraine. The new measures include a ban on the use of such medicines for migraine or bipolar disorder during pregnancy, and a ban on treating epilepsy during pregnancy unless there is no other effective treatment available. Further, the medicines must not be used in any woman or girl able to have children unless the conditions of a new pregnancy prevention programme are met. The programme is designed to ensure that patients are made fully aware of the risks and the need to avoid becoming pregnant. Companies marketing these medicines are also required to carry out additional studies on the nature and extent of the risks and to monitor valproate use and the long-term effects from affected pregnancies.

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