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It is a condition in which there is loss of spinal motor neurons and neurons of descending motor pathways from pyramidal cells of the cerebral cortex. The disease results in rapidly buy tofranil 25 muscular weakness, muscle atrophy, fasciculations, spasticity, difficulty speaking, difficulty swallowing and difficulty breathing. Usually the disease is progressive and fatal with most patients dying from respiratory failure and pneumonia within two to three years from onset. (A notable exception to this generalization is Professor Stephen Hawking who was diagnosed with motor neuron disease at the age of later, albeit paralysed for most of that time. ) The cause of motor neuron disease is unknown.

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