Manufacturer: GlaxoSmithKline. Lamotrigine Lamictal 50 mg Tablet: Each tablet contains 50 mg of Lamotrigine. Lamotrigine Lamictal mg Tablet: Each tablet contains mg of Lamotrigine. Pharmacology: Pharmacodynamics: Mechanism of Action: The results of pharmacological studies suggest that lamotrigine is a use-dependent blocker of voltage-gated sodium channels. Pharmacodynamic Effects: In tests designed to evaluate the central nervous system effects of drugs, the results obtained using doses of mg lamotrigine administered to healthy volunteers did not differ from placebo, whereas both mg phenytoin and 10 mg diazepam each significantly impaired fine visual motor coordination and eye movements, increased body sway and produced subjective sedative effects. In another study, single oral doses of mg carbamazepine significantly impaired fine visual motor coordination and eye movements, while increasing both body sway and heart rate, whereas results with lamotrigine at doses of mg and mg did not differ from placebo. Clinical studies: Clinical efficacy and safety of adjunctive therapy in patients aged 1 to 24 months with partial seizures: The effectiveness of lamotrigine as adjunctive therapy in patients aged 1 to 24 months with partial seizures was evaluated in a multi-centre, double-blind, placebo-controlled add-on trial Study LAM

Lamotrigine may exacerbate seizures in patients with myoclonic seizures including juvenile myoclonic epilepsy, Dravet syndrome, and Lennox-Gastaut syndrome. Aggression; agitation; arthralgia; diarrhoea; dizziness; drowsiness; dry mouth; fatigue; headache; irritability; nausea; pain; rash; sleep disorders; tremor; vomiting. Confusion; conjunctivitis; disseminated intravascular coagulation; face oedema; fever; haemophagocytic lymphohistiocytosis; hallucination; hepatic disorders; lupus-like syndrome; lymphadenopathy; meningitis aseptic; multi organ failure; nystagmus; seizure; severe cutaneous adverse reactions SCARs ; tic. Serious skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have developed especially in children ; most rashes occur in the first 8 weeks. Rash is sometimes associated with hypersensitivity syndrome and is more common in patients with history of allergy or rash from other antiepileptic drugs. Consider withdrawal if rash or signs of hypersensitivity syndrome develop.

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Glaxo SmithKline Pharmaceuticals Ltd. Product introduction Lamictal XR mg Tablet is an anti-epileptic medication that is used to treat two conditions, epilepsy and bipolar disorder. It works by blocking the signals in the brain that trigger epileptic seizures fits and in another way to prevent extreme mood swings. Lamictal XR mg Tablet can be used alone or in combination with other medicines. It may be taken with or without food. Your doctor will decide the correct dose for you.

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Lamotrigine is used alone or together with other medicines to help control certain types of seizures eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. It can also be used in the treatment of bipolar disorder manic-depressive illness in adults. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Tell your doctor if you have ever had any unusual or allergic reaction to lamictal 200 mg medicine or any other medicines.

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Lamotrigine has emerged with a distinct place in the pharmacological treatment of bipolar disorder, with the potential to treat and prevent bipolar depression, which is the dominant and arguably most disabling and under-treated phase of the illness. However, this relative inadequacy compares favorably with the alternative treatment options for bipolar depression, which are marked by poor efficacy or risk of polarity switch. The designation of lamotrigine as first-line treatment for bipolar depression prophylaxis should be done in cognizance of this context, and it would seem prudent to await greater evidence of efficacy before designating lamotrigine as first-line treatment lamictal 200 mg other bipolar indications. Bipolar disorder has been estimated to have a population lifetime prevalence of between 0. The highly recurrent course of bipolar disorder Angst and Sellaro, its poor functional outcomes Mitchell et al and over-representation in the completed suicide population Rihmer and Kiss have been well-documented in the literature.

Lamotrigine monotherapy has emerged as a possible treatment for bipolar depression. It is not associated with weight gain and is less likely to cause neurocognitive adverse effects and sedation. Most patients tolerate it well. It does carry a risk of dangerous rashes, but the risk is minimized by slow dosage titration and alert monitoring. The rate now appears to be 0. None of lamictal 200 mg four studies found a statistical difference between lamotrigine and placebo.

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Lamictal is a medication used to treat epileptic seizures and also mood episodes in adults with bipolar disorder. Learn about its uses, side effects, dosages, and warnings here. Lamictal Generic Name: lamotrigine is an anti-convulsant medication prescribed in tandem with other medications to prevent and control epileptic seizures in children over age two, adolescents, and adults. It treats partial onset seizures, generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome. It is not known if Lamictal is safe or effective when prescribed as an anti-epileptic on its own. Lamictal can also be used to prevent the sudden mood changes that occur as a symptom of bipolar disorder in adults ages

Serious rashes requiring hospitalization including Stevens-Johnson syndrome and discontinuation of treatment have occurred in 0. Almost all life-threatening rashes have occurred within 2- 8 weeks of lamotrigine therapy, but they have also occurred after prolonged treatment; duration cannot be relied on as a means to predict the potential risk heralded by the first appearance of a rash. Although benign rashes also occur with lamotrigine, it is not possible to predict reliably which rashes will prove to be serious or life threatening. Discontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguring. Need to modify dosage if adding or discontinuing hepatic enzyme-inducing anticonvulsant drugs or valproic acid. Increased risk of hematologic effects eg, neutropenia, anemia, leukopenia, thrombocytopenia, aplastic anemia in patients with previous history of adverse lamictal 200 mg to any drug.

The precise mechanism s by which lamotrigine exerts its anticonvulsant action are unknown. Lamotrigine also displayed inhibitory properties in the kindling model in rats both during kindling development and in the fully kindled state. The relevance of these models to human epilepsy, however, is not known. One proposed mechanism of action of lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. In vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids e. The rate of serious lamictal 200 mg is greater in pediatric patients than in adults.

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