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In addition, oral Acyclovir Zovirax provided effective prophylaxis for herpes virus disease. Special Precautions: Infusion: In patients receiving Zovirax IV for infusion at higher doses eg, for herpes encephalitis, specific care regarding renal function should be taken, particularly when patients are dehydrated or have any renal impairment. Contraindications: Hypersensitivity to acyclovir or valacyclovir. The quantitative zovirax vial price between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not been established in humans, and virus sensitivity testing has not been standardized. Obese patients should be dosed at the recommended adult dose using Ideal Body Weight.

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Acyclovir sodium for injection is a sterile lyophilized powder for intravenous administration only. The pH of the reconstituted solution is approximately The pka's of acyclovir are 2. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes.

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Genital herpes severe initial episodes in immunocompetent patients. Herpes simplex in neonates, and as initial and recurrent treatment in immunocompromised patients. Herpes simplex encephalitis. Varicella zoster immunocompromised patients. Give by IV infusion over 1 hour.

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