Cigarette smoking remains the largest preventable cause of premature death in developed countries. Bupropion, the first non-nicotine based drug for smoking cessation was licensed in the United States of America US in and in the United Kingdom UK in for smoking cessation in people aged 18 years and over. Bupropion exerts its effect primarily through the inhibition of dopamine reuptake into neuronal synaptic vesicles. It is also a weak noradrenalin reuptake inhibitor and has no effect on the serotonin system. Bupropion has proven efficacy for smoking cessation in a number of clinical trials, helping approximately one in five smokers to stop smoking. Up to a half of patients taking bupropion experience side effects, mainly insomnia and a dry mouth, which are closely linked to the nicotine withdrawal syndrome.

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This is not a complete list of side effects and others may occur. The gum can be used in a number of ways, either replacing all cigarettes or replacing a certain number so you can cut down. It can also boost your motivation so you quit completely. Costco carries items in our warehouses which may not be available online. Find your nearest warehouse. Bupropion hydrochloride tablets should be swallowed whole and not crushed, divided, or chewed.

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